Introduction

Walk into any modern clinic in Gangnam, and you’ll likely hear about Rejuran Healer. Nicknamed the “baby skin injection,” it’s more than just another skin booster—it’s a regenerative treatment built on solid biomedical science. At Hugo Plastic Surgery, we’ve seen firsthand how this therapy transforms tired, fragile skin into something smoother, firmer, and healthier-looking. But what’s really happening under the surface?

To answer that, we have to go beyond marketing buzzwords and look at the cellular level. Because the true power of Rejuran Healer lies in its active ingredient: polynucleotides (PNs)—the molecular building blocks that help damaged tissue rebuild itself.

Let’s unpack what makes this treatment different, why it’s earned so much attention in South Korea’s dermatological and plastic surgery circles, and whether it’s the right step for your skin.

What Is Rejuran Healer, Really?

At its core, Rejuran Healer is an injectable skin rejuvenation treatment that uses PN (polynucleotide) technology to stimulate the skin’s own healing processes. It’s derived from salmon DNA fragments—a clean, biocompatible source that closely resembles human DNA. This is not filler. It’s not botox. It’s not just hydration. It’s cellular repair.

The treatment is commonly used for:

• Fine lines and crepey texture

• Enlarged pores

• Redness and sensitivity

• Acne scars

• Thinning skin, especially under the eyes and on the neck

Think of it as a reset button for skin that’s been damaged by age, UV rays, inflammation, or even past treatments that went too far.

How Polynucleotides Work: From Wound Healing to Skin Regeneration

To understand why Rejuran works, you have to understand how your skin heals.

Every time you get a cut, sunburn, or breakout, your skin kicks into repair mode—sending cells and proteins to the injury site to rebuild collagen, restore the skin barrier, and fight inflammation. But as we age, this process slows. The quality of collagen declines. Blood flow weakens. Inflammation lingers longer than it should.

This is where PNs come in.

Polynucleotides act like cellular messengers. When injected into the dermis, they:

• Stimulate fibroblasts, the skin’s collagen factories

• Increase production of extracellular matrix proteins, improving skin density and elasticity

• Enhance microcirculation, supporting oxygen and nutrient delivery to skin cells

• Reduce inflammatory cytokines, calming chronic low-grade irritation

• Encourage cell proliferation, especially of basal keratinocytes

The result isn’t instant plumpness like with hyaluronic acid, but a gradual strengthening and renewal of your skin’s foundational health. For many patients, the improvement feels more authentic—like you’ve been getting better sleep and drinking more water, but on a cellular level.

Why Korean Doctors Swear by It

In South Korea, where skin quality is everything, Rejuran has become a mainstay in clinics that prioritize subtle, natural enhancements. It’s especially popular with:

• Women in their 30s to 50s, who want to maintain youthful texture without looking “done”

• Post-procedure patients, using it to speed up healing after lasers or microneedling

• Patients with sensitive, redness-prone skin, who are not ideal candidates for harsher treatments

At Hugo Plastic Surgery, we often combine Rejuran with other regenerative treatments like fat grafting or fractional laser resurfacing—not to add volume or erase every wrinkle, but to restore skin tone and structure so the face looks naturally vibrant again.

What People Often Overlook: It’s Not Just About the Skin

One of the most overlooked aspects of Rejuran is its potential impact on the skin barrier and overall skin immunity.

In many patients with chronic sensitivity or redness, the real issue isn’t just dryness or broken capillaries—it’s a compromised epidermal defense system. Without a healthy barrier, your skin overreacts to everything: weather changes, new skincare, even mild pollution.

Because polynucleotides help rebuild skin architecture from within, many patients report that their skin becomes more resilient over time. They don’t flush as easily. Products sting less. Their skin feels like it belongs to them again—not like a fragile shell they have to tiptoe around.

That’s something topical creams can’t quite achieve.

Is Rejuran Healer the Same as Skinboosters or PRP?

Not exactly. Here’s a quick breakdown of how they differ:

Each has its place. But for deep skin repair—especially if your goal is to rebuild structure and elasticity from the inside out—Rejuran is often the treatment of choice.

What to Expect: Timeline and Sessions

Rejuran isn’t a one-and-done solution. To be honest, it takes patience.

Most patients receive 3 to 4 treatments spaced 3–4 weeks apart, followed by maintenance every 6 months. Improvements are gradual. You might start noticing better hydration and glow after two sessions, but the full strengthening effect typically appears around 2–3 months in.

Post-treatment, some patients experience:

• Mild swelling or redness for 1–2 days

• Tiny injection bumps that fade within 24–48 hours

• A temporary “tight” feeling

No downtime, no peeling, no flaking—just quiet internal repair.

Who Should Consider It?

If you’re wondering whether Rejuran Healer is right for you—you’re not alone. It’s an ideal option if you:

• Feel like your skin has “lost its bounce” or is becoming thinner

• Experience frequent redness or sensitivity

• Have post-acne scarring or residual pigmentation

• Want to complement a more structural procedure (like a facelift or fat graft)

• Are in your late 20s to 50s and want to preserve youthfulness without volume or drastic change

We often recommend it as part of a preventive anti-aging strategy—particularly for patients in their 30s who want to stay ahead of collagen loss, or for those looking to recover skin integrity after aggressive treatments.

Final Thoughts: Skin Health as a Long Game

At Hugo Plastic Surgery, we see skin as more than a canvas—it’s an active, dynamic organ that deserves care on a molecular level. Rejuran Healer isn’t about chasing trends or looking airbrushed. It’s about restoring what’s already yours, making your skin stronger, calmer, and more youthful in its behavior—not just its appearance.

If you’ve struggled with sensitive skin, early aging signs, or scarring that lingers despite your best efforts, this treatment might be your quiet breakthrough.

Ready to restore your skin from within?
Consult with Dr. Seonghyeok Yang at Hugo Plastic Surgery in Gangnam, where science meets artistry in every skin-renewing injection.